Evaluation Of Dental Pulp Stem Cell Differentiation Pathways Under Various Biomimetic Scaffolds For Regenerative Endodontic Procedures In Immature Permanent Teeth

Abstract

Regenerative endodontic procedures (REPs) represent a promising approach for treating immature permanent teeth with necrotic pulp. These procedures rely on the differentiation potential of dental pulp stem cells (DPSCs) and the development of appropriate biomimetic scaffolds. This review explores the various differentiation pathways of DPSCs under different biomimetic scaffolds for REPs in immature permanent teeth. We examine the biological characteristics of DPSCs, their differentiation potential, and the influence of various biomaterials and scaffolds on their behavior. Current evidence suggests that the combination of appropriate bioactive materials with suitable scaffolds can significantly enhance DPSC differentiation toward odontoblast-like cells, promoting dentinogenesis and pulp-dentin complex regeneration. This article provides a comprehensive analysis of recent advances in biomimetic scaffolds and their applications in regenerative endodontics, offering insights into optimizing REPs for clinical applications.