Published 2026-02-15
Keywords
- Risperidone, High performance liquid Chromatography, Therapeutic range, Schizophrenia, Therapeutic drug monitoring.
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Abstract
To develop a simple, reliable method for quantifying serum Risperidone concentrations and correlating them with clinical outcomes.61 Schizophrenic patients were included in the study of which 24 were females and 37 were males who were on Risperidone. Serum Risperidone concentrations were measured by using HPLC and a brief psychiatric rating scale was employed to assess the course of the illness. Statistical analysis was done using the Unpaired t-Test. The mean and standard deviation of a large sample comparison utilising an unpaired t-test were used to express the data.Out of 61 samples Serum Risperidoneconcentrations in 19 patients were found to be in therapeutic range, 38 patients were found to be in sub therapeutic range,4 are above therapeutic range.In order to optimize a patient's dosage and Clinical practice in psychiatric facilities must include monitoring of therapeutic drugsin order to establish a correlation between serum concentration using clinical assessment scales.