This study aims to investigate cultural integration and the impact of health music on patient care in Hainan’s medical institutes. A mixed-methods approach was used, combining qualitative insights from interviews and focus group with quantitative data from surveys. The qualitative data provided in depth understanding of participant’s’ and experiences, while the quantitative data, analyzed using ANOVA quantified the effectiveness of cultural integration and health music practices. The findings revealed that culturally integrated music therapy significantly enhances patient comfort, emotional wellbeing, and overall therapeutic outcomes. Patients reported feeling more connected and receptive to therapy when it included culturally familiar music. Quantitative analysis showed significant improvement in patient outcomes and staff wellbeing associated with higher effectiveness scores in cultural integration and health music practices. Culturally integrated music therapy has the potential to substantially improve patient outcomes and healthcare staff wellbeing. By addressing challenges such as language and music preferences, perceptions of traditional versus modern healing and limited awareness, healthcare providers can foster a more inclusive and effective environment.