Innovation and entrepreneurship education plays an important role in the employment and entrepreneurship of graduates, but there are real problems such as neglecting social practice activities and a weak sense of social responsibility among students. In this paper, based on analyzing the role of Civic Education integrated into Innovation Education and the cultivation of sense of social responsibility by dual-creation education, ten universities in S province are selected as the research object, and the structural equation model is constructed through the research hypotheses. Reliability analysis was carried out based on the data obtained from the questionnaire, and the fitness of the research hypothesized model was examined using AMOS software. The degree of influence of entrepreneurship education on social responsibility was explored based on the path coefficients, and the mediating effect of political education between innovation and entrepreneurship education and social responsibility was investigated. The path coefficients of Civic and Political Education on the sense of social responsibility were 0.287 and 0.349 (P<0.01). The synergistic integration and development of Political Education can help to significantly improve students' sense of social responsibility and cultivate high quality and high moral standard social talents.