Purpose: Under the background of the integration of culture and tourism , this paper takes the local culture and tourism resources of Macao as the research object, and constructs the design method of regional characteristic architectural cultural and creative products from the perspective of semiotics , so as to design cultural and creative products with Macao characteristics and promote the high-quality development of Macao's cultural and tourism industry . Methods: Firstly, the basic theory of semiotics is explained and the constituent elements of visual cultural symbols are analyzed; then the cultural and tourism resources in Macao are sorted and screened, and the most recognizable and artistic projects are selected; the graphic elements of visual cultural symbols are extracted from the two aspects of signifier and signified of semiotics, and the graphic elements are redesigned by borrowing and metaphor to form new signifiers and signifieds of symbols and apply them to the design of cultural and creative products . Conclusion: The design practice plan shows the effectiveness of using semiotic methods to design regional characteristic architectural cultural and creative products in Macao ; this method can be used to design rich and diverse cultural and creative products, realize the dissemination of regional culture, and provide a new path for the development and utilization of local characteristic cultural and tourism resources.