This article explores the importance of abandoned industrial heritage in urban regeneration and the theory and practice of its spatial design. First, the article elaborates on the theoretical basis of urban regeneration and place memory, emphasizing the historical, cultural and economic value of abandoned industrial heritage. Then, successful reuse cases at home and abroad are analyzed to demonstrate the embodiment of place memory in design. The article further explores the application of philosophical thinking in the spatial design of abandoned industrial heritage, pointing out the influence of sustainable development, humanism, aesthetics and ethical philosophy on design. Subsequently, the article analyzes the challenges faced by the spatial design of abandoned industrial heritage and proposes corresponding countermeasures. Finally, the article looks forward to the future design trends of abandoned industrial heritage spaces in cities, including the development of intelligent technology, green ecological concepts, multicultural integration and community participation. These trends are of great significance to the development of Chinese cities and provide new ideas and motivation for achieving sustainable urban development.