In the field of pedagogical research, this study focuses on the practical path of integrating regional characteristic culture into ideological and political education and the mining of educational value. As a valuable wealth formed by the long-term accumulation of a specific region, regional characteristic culture is closely related to ideological and political education. It not only conforms to the goals of ideological and political education in terms of connotation, but also injects new vitality into ideological and political education with its unique regional and diverse characteristics. This paper constructs a comprehensive practice model, and at the classroom teaching level, the case teaching method, the situational teaching method and special lectures are adopted to vividly integrate the regional characteristic culture into the ideological and political classroom. Practical teaching enhances students' practical experience through field trips, cultural activity competitions, volunteer services, etc. The construction of campus culture creates a strong cultural and educational atmosphere from the aspects of creating cultural landscapes, supporting club activities, holding cultural festivals and theme exhibitions. Through specific case analysis, the successful experience was summarized, and corresponding solutions were put forward for the challenges of cultural resource mining and integration, insufficient teachers' literacy ability, lack of students' interest and imperfect evaluation system, so as to build a solid theoretical and practical foundation for promoting the deep integration of the two and effectively improving the quality of ideological and political education.