Workplace stress remains a significant concern in the nursing profession, directly influencing the quality of patient care and the well-being of healthcare providers. This study explores the impact of work-related stress on nursing performance in Makkah healthcare settings. A standardized questionnaire was used on a sample of 120 registered nurses selected from three major health facilities in Makkah City. These critical were heavy patient-nurse workload, resource inadequacy, and interpersonal conflict that were found to exert such debilitating effects on task efficiency and patient communication. In reporting compromised ability to balance responsibilities and maintenance of performance standards, levels of stress had reached high levels. Coping mechanisms included peer support and mindfulness practices, which are relieving to a moderate extent; at a deeper level, however, the systemic organizational issues remain unaddressed. This shows clearly the dire need for policy reform and supportive system intervention that could minimize stress and improve work conditions for nurses. These findings send an important message to healthcare administrators and policymakers, showing how organizational performance can be improved in response to high workload pressure without compromising the well-being of the staff.