The practice of Buddhism in China and its interaction with native Chinese culture from the 2nd to the 3rd centuries AD. has been the focus of scholarly attention. By analyzing literature and archaeological data from the Eastern Han dynasty, scholars have concluded that 1) Buddhism was attached to Daoism and 2) orthodox Buddha statues date back to the 4th century AD. In fact, during the Eastern Han period, the interaction between Buddhism and the diverse native cultures of different regions of China took on different characteristics. Based on the newly discovered 、 bronze Buddha statues in Shaanxi indicates that there was orthodox Buddha statue worship and that Buddhist beliefs existed in the Chang’an area during the Eastern Han period in the mid-2nd century AD. In addition, the interaction of Buddhism with indigenous Chinese culture, beliefs and practices presents the following three aspects: 1) different understandings of Buddhism among different classes; 2) strong interaction with the beliefs and worship of Xiwangmu; and 3) inclusion in the Yin-Yang system. We find that they not only express the different understandings held by Chinese people on Buddhism in different regions and at different times, but also reflect a secularized form of belief in Buddhism in China. Therefore, the purpose of this paper is to attempt to add to and revise the existing research.