Key cadres at the commune level play an important role in organizing the implementation of socio-economic development tasks and ensuring security and national defense in the locality. Recognizing this, Party committees and authorities at all levels in the Mekong Delta, Vietnam have focused on building a contingent of cadres with strong qualities, capacity and political will. Thanks to that, after nearly 40 years of renovation, the political culture of the majority of key cadres at the commune level has been continuously improved, demonstrated through a sense of responsibility, standards of conduct and capacity to perform tasks. Many typical examples of political culture have become quality human resources, contributing to the sustainable development of the region. However, besides the achieved results, there are still some key cadres at the commune level who have shown limitations such as lack of standards in political behavior, low work efficiency, and even signs of ideological and moral degradation, affecting people's trust in the Party and State. Part of the reason is due to the lack of awareness of the importance of political culture, and the training and fostering work has not really received due attention. In the face of the requirements of innovation and integration, building a team of key cadres at the commune level with political courage, pure ethics, high professional qualifications, and standard working style is an urgent task. This is not only a key factor to consolidate the grassroots political system but also an important contribution to the common development of the Mekong Delta and Vietnam in the era of national development.