Complex procedures require the integration of anesthesia and dentistry, which is crucial, but major obstacles to interdisciplinary cooperation exist and are intensified by the uneven usage of modern technology. There is a gap in knowledge on how digital tools can have a quantitative effect on this professional partnership. In line with this, the current research paper was able to perform a systematic review of the contemporary circumstances of technology-mediated collaboration and formalize the essential predictors of effective collaboration. It was a mixed-methods, exploratory study, which included 200 professionals (100 dental practitioners and 100 anesthesiologists). Structured questionnaires and semi-structured interviews were used to gather data, which were analyzed using descriptive statistics, independent-samples t-tests, Pearson correlation, and multiple regression analysis carried out in SPSS. Findings showed that there was a significant difference in the adoption of technology, with anesthesiologists (Mean = 4.0) scoring higher than dental professionals (Mean = 3.6; p =.02). The technology adoption and the level of satisfaction with collaboration (r =.58, p <.01) were found to be strongly related. The adoption of technology was the strongest predictor of collaboration satisfaction ( =.45, p =.001) as confirmed by multiple regression analysis with the overall model explaining 63% of the variance (R 2 =.63). These results provide conclusive evidence that modern technology can be considered as an enabler of inter professional collaboration. The current study presents a research-backed model of clinical practice, which indicates that the specific technological integration, especially in the dental context, is a key approach to improving collaboration, streamlining working processes, and eventually to better patient safety and care outcomes in the practice of dental anesthesia.