Healthcare-associated infections (HAIs) remain a persistent threat to patient safety, workforce wellbeing, and the financial sustainability of health systems worldwide. In Saudi Arabia, rapid expansion of healthcare infrastructure, high patient turnover in tertiary facilities, large-scale mass gatherings, and a diverse healthcare workforce create a unique infection prevention and control (IPC) landscape. This research paper examines infection control practices in Saudi hospitals with a focus on practical strategies for prevention and continuous improvement in healthcare settings. The paper synthesizes core IPC pillars—governance, surveillance, standard and transmission-based precautions, environmental hygiene, sterilization and disinfection, antimicrobial stewardship, occupational health, training, and patient engagement—and discusses how these can be strengthened through quality improvement, safety culture, and data-driven decision-making. It highlights common system-level barriers such as inconsistent adherence to hand hygiene, variability in isolation capacity, staffing and workload pressures, gaps in audit feedback, and uneven integration of IPC with clinical operations. The paper proposes a structured improvement framework built on risk assessment, measurable indicators, targeted interventions, and sustained monitoring. Special attention is given to high-risk areas (ICUs, operating theaters, dialysis units, emergency departments) and high-priority organisms and syndromes (multidrug-resistant organisms, central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated events, and surgical site infections). Recommendations emphasize leadership accountability, standardized workflows, competency-based training, digital surveillance, environmental and engineering controls, and culture change approaches that support reliable practice. The conclusion underscores that effective IPC in Saudi hospitals requires not only policies and protocols, but also consistent implementation supported by leadership, resources, and continuous improvement systems.