This systematic review delves into the profound influence of transformational leadership on enhancing nursing practice. In the dynamic and ever-evolving healthcare landscape, effective leadership is crucial for cultivating a resilient, innovative, and high-performing nursing workforce. Transformational leadership, characterized by its core components of idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration, has emerged as a pivotal style capable of inspiring positive change and driving superior outcomes within the nursing profession. This review synthesizes findings from recent systematic reviews and empirical studies published between 2020 and 2025. It meticulously examines how transformational leadership impacts various critical facets of nursing practice, including but not limited to job satisfaction, organizational commitment, nurse retention, the quality of patient care, and the overall work environment. The comprehensive synthesis of evidence consistently reveals a strong positive correlation between the behaviors associated with transformational leadership and improved nursing outcomes. This highlights its indispensable role in fostering a healthy and supportive work environment, promoting continuous professional development, and ultimately elevating the standards of patient care. The findings emphatically underscore the imperative for healthcare organizations to strategically invest in robust leadership development programs. These programs should be designed to cultivate and nurture transformational qualities among nursing leaders, enabling them to effectively navigate complex challenges and ensure the sustainable delivery of high-quality healthcare services.