The increasing complexity of healthcare systems has highlighted the limitations of fragmented, department-specific approaches to patient care. As healthcare organizations move toward value-based and outcome-oriented models, there is a growing need for system-wide patient strategy development that integrates the contributions of all medical departments. This review aims to synthesize current evidence on how coordinated, interprofessional collaboration across clinical, diagnostic, supportive, and administrative departments contributes to the development of effective patient strategies and improved health outcomes. Using an integrative review approach, studies published in peer-reviewed journals were analyzed to examine coordination mechanisms, care continuum alignment, and outcome-based care models. The findings indicate that patient strategies developed through system-wide collaboration are associated with improved clinical outcomes, enhanced patient experience, increased safety, and more efficient use of healthcare resources. Key enabling factors include multidisciplinary teamwork, shared governance structures, digital health integration, and standardized yet flexible care pathways. Conversely, organizational silos, communication gaps, and misaligned performance metrics remain significant barriers. This review underscores the importance of adopting a holistic, system-level perspective when designing patient strategies and provides insights for healthcare leaders, policymakers, and researchers seeking to strengthen interprofessional coordination and advance outcome-based care models.