Postpartum depression (PPD) is a significant public health concern that affects maternal well-being, infant development, and family stability. Early prevention strategies are increasingly recognized as essential components of maternal healthcare. This paper aims to analyze the role of nursing, midwifery, and social work professionals in the prevention of postpartum depression through brief psychological interventions and structured social support. Using an analytical methodology, the study reviews and synthesizes findings from relevant international literature to explore how multidisciplinary healthcare teams contribute to early detection, prevention, and psychosocial support for at-risk mothers. The analysis highlights the effectiveness of brief psychological interventions, such as psychoeducation, counseling, and emotional support, when delivered by trained healthcare professionals during the prenatal and postnatal periods. Additionally, the paper emphasizes the importance of social support mechanisms facilitated by social workers in reducing psychosocial stressors associated with postpartum depression. The findings underscore the necessity of integrated, collaborative care models that combine clinical, psychological, and social approaches to improve maternal mental health outcomes. The paper concludes with recommendations for clinical practice and future research aimed at strengthening multidisciplinary prevention strategies for postpartum depression.