Aims and Objectives: To accumulate the current knowledge on the meaning of trust as it relates to patients’ perception of nursing. The review question was “How do patients describe the meaning of trust in the nursing relationship?” Background: Trust is crucial in nursing as it offers a way by which the human being can develop trust, optimism and purpose in life as well as provide a way of encountering the world. Trust is an interpersonal and essential element of all patient-nurse relationships and therefore it is important for nurses to develop trust with the patients. Design: This article is a systematic qualitative literature review. Methods: The database search was conducted for the period of August 2024 to October 2024 and updated in the month of January 2014. 20 papers were included. Results: Four categories emerged: Attitudes related to trust, highlighting the fact that trust is inevitable and inherent; Experiences of trust, the mechanicals of identifying trust; The patient-nurse relationship, revealing the characteristics of the person who generates trust; and Where trust occurs, identifying the contexts of trust. Conclusions: The trust that patients place in nursing is a function of the knowledge that the nurses have, the amount of effort that the nurses are willing to put in the process of developing the relationship and other contextual factors. Im- plications for nursing practice: It is essential to think about the trust that the patient has for the nurse in order to gain a better understanding of what trust in nursing actually means. Clinical nurse researchers nurse supervisors, managers and nurse educatorsshould ensure that they discuss various aspects of trust during the course of nursing supervision and focus-group meetings as well as with the nursing graduates in order to enhance the nurses’ understanding on how to establish a trusting relationship with the patient.