Healthcare settings present unique security challenges, with workers facing elevated risks of workplace violence and other safety concerns. This comprehensive analysis examines healthcare workers' preferences and priorities regarding safety climate and security infrastructure across various practice settings. Drawing on recent research and industry standards, this study explores the multidimensional nature of healthcare security needs, from physical infrastructure to organizational policies and interpersonal dynamics. Through examination of evidence from emergency departments, psychiatric units, general hospital settings, and community health centers, we identify key factors that influence worker preferences for security measures. Findings indicate that healthcare workers prioritize visible security presence, comprehensive training, clear response protocols, administrative support, and technological solutions tailored to specific practice contexts. The article concludes with evidence-based recommendations for healthcare organizations to enhance safety climate and security infrastructure in ways that align with worker preferences while maintaining therapeutic environments. This analysis contributes to the growing body of knowledge on healthcare security by centering worker perspectives in the development of effective, context-sensitive security approaches.