Background: Lifestyle is defined as a group of personnel's daily habits and behavioral patterns sustained over time, such as diet, physical activity, and behavior. Objective: assess healthy lifestyle patterns among adults in Jazan, Saudi Arabia. Materials and Methods: A cross-sectional study was conducted among 422 students from Jazan University in Jazan region. A multistage cluster random sampling technique was used. The self-administered questionnaire includes sociodemographic, FANTASTIC lifestyle, and EuroQol 5-Dimension 3-level (EQ-5D-3L).

Results: 424 students participated in the study, with a response rate of 46.7% male and 53.3% female. The average age of students was 22.47 years, and most of them (56.6%) lived in villages. The students had a good lifestyle, with a mean score of 32.7995 ± 6.49 on the FANTASTIC questionnaire. The mean EQ-5D-3L index score was 0.87 ± 0.15. The study demonstrated a positive correlation between lifestyle status and health-related quality of life (HRQoL). Additionally, male students were found to have an excellent lifestyle more often than female students.

Conclusion: The findings from the study utilizing the Fantastic questionnaire and EQ-5D dimensions point to the potential benefits of interventions to enhance the healthy lifestyles and HRQoL of Jazan University students. This can be achieved through educational programs and the promotion of health initiatives, with a specific focus on addressing anxiety and depression among students.