Oral health remains a frequently overlooked yet critical component of comprehensive palliative care. Patients in palliative care settings often experience significant oral health complications that negatively impact their quality of life, nutrition, communication, and dignity during their final stages of life. Despite the recognized importance of oral care, there exists a substantial gap in structured interdisciplinary approaches to oral healthcare research in palliative settings. This study presents a framework for meaningful collaboration between dental and nursing professionals to advance oral healthcare research in palliative inpatient environments. By examining current challenges, identifying opportunities for interprofessional cooperation, and outlining methodological considerations specific to this vulnerable population, this framework seeks to address the existing research-practice gap. Through intentional partnership between dental expertise and nursing's continuous bedside presence, this collaborative model aims to improve assessment tools, intervention strategies, and implementation approaches for oral care in palliative settings, ultimately enhancing patient comfort and dignity at the end of life.