Evaluation Of Dental Pulp Stem Cell Differentiation Pathways Under Various Biomimetic Scaffolds For Regenerative Endodontic Procedures In Immature Permanent Teeth
VOLUME 21, 2024
The Role of Targeted Infra-popliteal Endovascular Angioplasty to Treat Diabetic Foot Ulcers Using the Angiosome Model: A Systematic Review
VOLUME 6, 2023
Omar Sultan Alosaimi, Riyadh Mohammed Albadr, Faisal Abdulrahman Alkharisi, Meshal Fawaz Alshammari, Kholoud Abdullah Alnemer, Alanoud Bassam Albalawi, Ali Mohammed Alfareh
Hatem Khaled Alahmary, Alharith Hani Sagga, Mohammed Turaid Alanazi, Abdulmuhsen Saad Nasser Jafel, Ashwag Moohmaed Alahmari, Tagreed fahad Al Dosry
Abstract
Regenerative endodontic procedures (REPs) represent a promising approach for treating immature permanent teeth with necrotic pulp. These procedures rely on the differentiation potential of dental pulp stem cells (DPSCs) and the development of appropriate biomimetic scaffolds. This review explores the various differentiation pathways of DPSCs under different biomimetic scaffolds for REPs in immature permanent teeth. We examine the biological characteristics of DPSCs, their differentiation potential, and the influence of various biomaterials and scaffolds on their behavior. Current evidence suggests that the combination of appropriate bioactive materials with suitable scaffolds can significantly enhance DPSC differentiation toward odontoblast-like cells, promoting dentinogenesis and pulp-dentin complex regeneration. This article provides a comprehensive analysis of recent advances in biomimetic scaffolds and their applications in regenerative endodontics, offering insights into optimizing REPs for clinical applications.
Keywords :
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Erin Saricilar
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.
Abstract
Atherosclerotic disease significantly impacts patients with type 2 diabetes, who often present with recalcitrant peripheral ulcers. The angiosome model of the foot presents an opportunity to perform direct angiosome-targeted endovascular interventions to maximise both wound healing and limb salvage. A systematic review was performed, with 17 studies included in the final review. Below-the-knee endovascular interventions present significant technical challenges, with technical success depending on the length of lesion being treated and the number of angiosomes that require treatment. Wound healing was significantly improved with direct angiosome-targeted angioplasty, as was limb salvage, with a significant increase in survival without major amputation. Indirect angioplasty, where the intervention is applied to collateral vessels to the angiosomes, yielded similar results to direct angiosome-targeted angioplasty. Applying the angiosome model of the foot in direct angiosome-targeted angioplasty improves outcomes for patients with recalcitrant diabetic foot ulcers in terms of primary wound healing, mean time for complete wound healing and major amputation-free survival.
Keywords :
Diabetic foot ulcer, angiosome, angioplasty