Background: Serious games in medical education have demonstrated benefits in student adherence, motivation, and active participation in simulated practices, improving teaching-learning processes, professional training, and academic performance.

Methods: A mixed-methods descriptive study on the design, perception, and evaluation of a group of medical students subjected to "Medical Olympics," an educational strategy through interdisciplinary simulation.

Results: Three phases were established for the development of the activity over an average period of 2 weeks, including 300 undergraduate medical students in clinical courses. Empathy and compassion, critical thinking (61%), and ethical responsibility were the main competencies evaluated during the event. Most students were satisfied with the strategy, highlighting its benefits and differentiating factors for their professional training.

Discussion: The incorporation of interactive pedagogical methods and serious games in medical education has demonstrated benefits in learning, knowledge retention, and decision-making. Strategies like the "Medical Olympics" promote competencies through quantitative assessments, improving skills and fostering interdisciplinary collaboration, aligned with current learning theories and evidence.

Conclusion: Serious games in medical education improve the handling of clinical problems in students, reinforcing both theoretical learning and technical and non-technical skills in a safe and controlled environment. Although positively evaluated, it is recommended to standardize assessments and use emerging technologies for greater effectiveness.