Cultura

Development of a System Based on Convolutional Neural Networks for the Classification of Alzheimer’s Magnetic Resonance Images

VOLUME 21, 2024

The Role of Targeted Infra-popliteal Endovascular Angioplasty to Treat Diabetic Foot Ulcers Using the Angiosome Model: A Systematic Review

VOLUME 6, 2023

Diego A. Peláez-Carrillo, Oscar E. Gualdrón-Guerrero, Ezequiel Jose Valencia Urbina

Abstract

This work presents the development of a convolutional neural network (CNN) for the classification of Alzheimer’s magnetic resonance imaging (MRI) scans, with the aim of optimizing the early diagnosis process of the disease through the use of digital image processing. Alzheimer’s diagnosis faces a significant challenge due to the need for precise and rapid identification of the different stages of the disease, which can enhance medical care and improve patients' quality of life.

To address this issue, a dataset consisting of MRI images obtained from the Kaggle platform was used, which includes a wide variety of brain images at different stages of the disease. The images were categorized into three classes: "No Alzheimer’s," "Mild," and "Advanced". The methodology involved designing three CNN models with different configurations of convolutional layers, dense layers, and regularization techniques, as well as preprocessing the images by converting them to grayscale and normalizing pixel values. The training process incorporated data augmentation techniques and hyperparameter tuning to improve the model’s accuracy.

Model 3, which had the best configuration, achieved an accuracy of 95.1% and a loss of 0.32, standing out as the most efficient in classifying the images. The results were evaluated using confusion matrices, which demonstrated the model's ability to correctly classify Alzheimer’s images into the three categories.

This innovative approach not only improves the efficiency of Alzheimer’s disease diagnosis but also facilitates the implementation of a medical decision- support system. The successful implementation of this technology represents a significant opportunity to modernize traditional diagnostic imaging methods, contributing to the advancement of precision medicine and the development of artificial intelligence technologies applied to healthcare.

Keywords : Convolutional Neural Networks, Classification of Alzheimer’s, Magnetic Resonance Images.
Erin Saricilar
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.

Abstract

Atherosclerotic disease significantly impacts patients with type 2 diabetes, who often present with recalcitrant peripheral ulcers. The angiosome model of the foot presents an opportunity to perform direct angiosome-targeted endovascular interventions to maximise both wound healing and limb salvage. A systematic review was performed, with 17 studies included in the final review. Below-the-knee endovascular interventions present significant technical challenges, with technical success depending on the length of lesion being treated and the number of angiosomes that require treatment. Wound healing was significantly improved with direct angiosome-targeted angioplasty, as was limb salvage, with a significant increase in survival without major amputation. Indirect angioplasty, where the intervention is applied to collateral vessels to the angiosomes, yielded similar results to direct angiosome-targeted angioplasty. Applying the angiosome model of the foot in direct angiosome-targeted angioplasty improves outcomes for patients with recalcitrant diabetic foot ulcers in terms of primary wound healing, mean time for complete wound healing and major amputation-free survival.
Keywords : Diabetic foot ulcer, angiosome, angioplasty