Introduction: Ayurveda conceptualizes digestion as the central process governing physical health, mental balance, and harmony with natural rhythms. Rather than limiting digestion to a biochemical function, Ayurvedic thought integrates food, mental regulation, ethical conduct, cultural practices, and seasonal adaptation into a unified model of health. This review examines the cultural and philosophical dimensions of digestion in Ayurveda, highlighting the interrelationship between dietary practices, mental well-being, and seasonal harmony in maintaining metabolic balance and preventing disease. Central to this framework is Agni (digestive–metabolic fire), which regulates transformation and assimilation, while impairment of digestion leads to the formation of Āma, a state of metabolic incompleteness underlying disease processes.

Methods: A narrative review of classical Ayurvedic texts, including the Caraka Saṃhitā, Suśruta Saṃhitā, and Aṣṭāṅgahṛdaya, along with allied Indian philosophical texts that inform Ayurvedic concepts of digestion, food, and consciousness (e.g., Upaniṣadic and Gītā literature), was conducted to analyze principles related to digestion, dietetics, mental regulation, cultural etiquette, and seasonal adaptation. Contemporary scientific literature on metabolism, gut–brain interactions, circadian biology, stress physiology, and lifestyle related disorders was selectively reviewed to contextualize these traditional perspectives within current biomedical understanding.

Results: The review identifies Agni, Āma, Sātmya (dietary habituation), mindful eating, and seasonal adaptation as foundational determinants of digestive and mental health. Food is presented not only as nutritional input but as a culturally and philosophically significant factor influencing tissue nourishment, metabolic efficiency, and mental clarity. Emotional disturbances, sensory excess, irregular eating patterns, and neglect of seasonal rhythms consistently emerged as contributors to digestive dysregulation. Cultural rituals, dietary etiquette, regional food practices, and seasonal observances were shown to reinforce digestive balance by aligning human behavior with environmental and biological rhythms.

Conclusion: Ayurveda presents digestion as a psycho-physiological, cultural, and seasonal process essential to holistic health. Integrating these classical principles with contemporary scientific perspectives may offer sustainable approaches to improving digestive regulation, mental well-being, and the prevention of lifestyle related disorders.