Laboratory Information Systems (LIS) have become foundational to modern clinical laboratory operations, influencing workflow efficiency, diagnostic accuracy, turnaround time, and overall service quality. In Saudi Arabian hospitals, rapid digital transformation aligned with national health reform initiatives has increased reliance on integrated health information technologies. However, the relationship between LIS user satisfaction and measurable laboratory service quality outcomes remains insufficiently synthesized in the regional context. This review examines the association between LIS user satisfaction and laboratory service quality in Saudi hospitals through systematic analysis of peer-reviewed literature. A structured search following PRISMA 2020 guidance was conducted using PubMed, Scopus, and Web of Science. Findings indicate that user satisfaction is strongly associated with system usability, perceived usefulness, training adequacy, technical support, and interoperability. High LIS satisfaction correlates with improved turnaround time, reduced transcription errors, enhanced reporting accuracy, and improved clinician-laboratory communication. Conversely, dissatisfaction is associated with workflow disruption, delayed reporting, and increased risk of pre-analytical and post-analytical errors. Organizational culture, leadership engagement, and continuous quality improvement programs mediate the strength of this relationship. Although regional empirical studies remain limited, available evidence supports a positive and bidirectional association between LIS satisfaction and laboratory service quality. Future Saudi-based studies should employ validated measurement models to quantify this relationship within public and private hospital settings.