Minimizing tissue trauma, patient recovery, and enhancing operation room (OR) workflows which pose operational questions at the integration. This is a mixed retrospective/prospective study to evaluate the effect of MIST on OR efficiency through 1,200 surgical procedures of varying specialties involving a 3-part case review of 1,000 cases, 200-time-motion analysis and a 140-survey of OR personnel. Both the MIST (n = 420; 35.0%) and conventional groups (n = 780; 65.0%) were compared through comparative analyses, and it was found that cases associated with MIST had reduced mean procedure times (104.3 +/-32.8 vs 120.6 +/-39.2 minutes, p < 0.01), turnover times (20.3 +/-6.8 vs 23.8 +/-7.6 minutes, p < 0 In sum, the implementation of MIST was linked to the increase of 14.5 percent in OR efficiency. There was a 28.01 (n = 336) percentage delay of which the case was mainly delayed by the unavailability of the equipment or equipment malfunction (30.0), unavailability of the staff (25.0), and problem with the patients (20.0). The results indicate that the integration of MIST leads to an improvement in various OR performance metrics and ought to be alongside specific interventions, including checks of equipments, standardised turnover processes, and multidisciplinary training, to realise maximum efficiency improvements and optimisation of surgical service delivery.