The delivery of care in emergency medicine and first aid environments is fraught with complex challenges, including time-sensitive decision-making, high patient acuity, and a lack of prior medical history. In these high-stakes settings, medication errors and adverse drug events pose significant threats to patient safety. The objective of this literature review is to critically analyze and synthesize existing literature on the integration of clinical pharmacy services within emergency departments, prehospital care, and disaster response scenarios, evaluating their contributions to medication safety and patient outcomes. The literature search was executed utilizing databases including PubMed, Scopus, Web of Science, and Google Scholar using various combinations of keywords related to clinical pharmacy, first aid, and emergency medicine. Key findings indicate that the inclusion of clinical pharmacists reduces medication errors by up to 73%, decreases time-to-treatment for time-critical conditions such as sepsis and myocardial infarction, and facilitates cost savings. However, their roles in prehospital care and disaster management remain underdeveloped and underutilized. In conclusion, the integration of clinical pharmacists in emergency and first aid situations yields measurable improvements in medication safety and patient care, highlighting the need for broader implementation and standardized training protocols.