This study aims to explore the impact of exorbitant expenses associated with Pre-exposure Prophylaxis (PrEP) on the prevalence of HIV and AIDS in marginalized rural communities in Zimbabwe. The rising costs of PrEP serve as a significant barrier, hindering access to crucial preventive measures. This research addresses a notable gap in existing literature regarding the socio-economic factors influencing PrEP uptake in rural settings, particularly focusing on groups disproportionately affected by these challenges. Employing a qualitative research approach, the study was framed within a constructivist research paradigm. A sample of 15 participants was purposively selected, considering gender, geographical location, age, and expertise. Data were collected through two focus group discussions: one comprising single women and another including diverse participants. To enhance the trustworthiness of the findings, data triangulation was employed. Thematic analysis, following Braun and Clarke's (2006) guidelines, was utilized to analyze the data while maintaining ethical considerations, including confidentiality and informed consent. Findings reveal that the financial burden of PrEP significantly deters its uptake, leading to increased vulnerability to HIV transmission among marginalized populations. One key recommendation is to implement subsidized PrEP programs aimed at lowering costs for rural communities, thereby fostering greater accessibility to preventive healthcare.