Interprofessional collaboration has been increasingly recognized as essential for optimizing rehabilitation outcomes following lower limb amputation. This literature review synthesizes evidence on collaborative practice among physical therapists, occupational therapists, and prosthetist-orthotists in post-amputation rehabilitation, with particular attention to the Saudi Arabian healthcare context. A comprehensive review of peerreviewed literature reveals that effective interprofessional teamwork contributes to improved functional outcomes, enhanced prosthetic acceptance, and superior quality of life for individuals with limb loss. Physical therapists primarily address mobility, strength, and gait training; occupational therapists focus on activities of daily living and psychosocial adaptation; while prosthetist-orthotists ensure optimal prosthetic fit and function. In Saudi Arabia, interprofessional collaboration faces unique challenges including hierarchical professional structures, limited interprofessional education, and communication barriers. However, emerging evidence suggests growing recognition of collaborative care models. This review identifies critical gaps in research specific to Gulf healthcare systems and emphasizes the need for culturally adapted interprofessional frameworks, standardized outcome measures, and systematic implementation of team-based care protocols in Saudi rehabilitation settings