The present study examined the relationship between employee engagement and job satisfaction among nurses in Kurnool District through the perspective of positive spillover. The research aimed to analyze employee engagement levels, evaluate the influence of positive spillover, and examine its impact on job satisfaction among nursing professionals. A descriptive and analytical research design was adopted, and primary data were collected from 200 nurses working in private hospitals using a structured questionnaire. Convenience sampling technique was employed for selecting respondents. Statistical tools such as descriptive statistics, correlation analysis, regression analysis, Exploratory Factor Analysis (EFA), and Structural Equation Modeling (SEM) were used for data analysis. The findings revealed that employee engagement significantly improved job satisfaction and emotional well-being among nurses. Positive spillover also positively influenced work-life balance and professional satisfaction. SEM results confirmed that positive spillover partially mediated the relationship between employee engagement and job satisfaction. The study emphasized the importance of supportive work environments, recognition systems, and employee-centered management practices in improving nurses’ organizational commitment and healthcare service quality.