This article discusses the innovation of innovation and entrepreneurship course construction from a philosophical perspective. First, through the discussion of the philosophical viewpoint of innovation, the essence and characteristics of innovation are revealed, and the relationship between innovation and human freedom and self-realization is discussed. Secondly, the philosophical basis for the construction of innovation and entrepreneurship courses is expounded from the aspects of the connection between philosophical thinking and innovative thinking, the role of philosophical education in cultivating innovation ability, and the connection between philosophical ethics and innovation and entrepreneurship. On this basis, the design principles of innovation and entrepreneurship courses based on a philosophical perspective are proposed, including the cultivation of individual subjectivity and autonomy, the cultivation of self-realization and innovation capabilities, and the relationship between social participation and innovation and entrepreneurship. Finally, through practical case analysis, the application of philosophical thinking cultivation in innovation and entrepreneurship courses, the practice of philosophical ethics education in innovation and entrepreneurship courses, and the evaluation and improvement of innovation and entrepreneurship courses from a philosophical perspective are discussed. The research in this article provides innovative ideas and guidance from a philosophical perspective for the construction of innovation and entrepreneurship courses, and helps promote the development of innovation and entrepreneurship education.